In fact, hypermethylation of SLC5A5 distal enhancer has been reported in thyroid tumors [33] and treatment with the demethylating agent 5‐aza‐2′‐deoxycytidine improved NIS expression and radioiodine uptake in FTC cells [33], though ineffective in ATC cells [34]. The gene discussed is SLC5A5; the disease is thyroid cancer, nonmedullary, 2.