Some forms of autoimmunity arise from mutations in disease‐resistance genes that alter the signaling pathways initiating HR, such as the gene rp1 in maize.[25] Other types of autoimmunity are caused by mutations in catalytic enzymes or metabolites involved in normal metabolic pathway.[26, 27] Examples include the maize gene les22, which disrupts the porphyrin metabolic pathway,[28] the modl gene in Arabidopsis, which impairs fatty acids biosynthesis,[29] and the LSD1 mutant in Arabidopsis, which leads to the rapid accumulation of O2‐ and H2O2. This evidence concerns the gene RP1 and Autoimmunity.