For example, the Hedgehog pathway acts as an oncogene in the early phases of tumor development but switches into a tumor suppressor as the cancer advances.[10] Similarly, activin signaling functions as a tumor suppressor during the initial stages of tumor formation, only to promote tumor progression and metastasis in the later stages.[11] In this context, we conducted a somatic‐to‐pluripotent stem cell reprogramming screen utilizing an shRNA library that targets 700 cancer‐related developmental genes. Here, INHBE is linked to cancer.