DKK3 and pancreatic neoplasm: Consistent with these roles, pancreatic tumors arising in heterozygous (DKC) and homozygous (DDKC) Dkk3‐deficient backgrounds display distinct histopathological features and TME landscapes. Notably, DKC mice exhibited even shorter survival than DDKC mice, despite loss of only a single Dkk3 allele in both epithelial and stromal compartments in our non‐conditional Dkk3‐deficient model crossed with pancreas‐specific oncogenic KRAS, indicating a non‐linear, dose‐sensitive effect of DKK3 across various tissue compartments (Figure 1J).