DKK3 and neoplasm: More than half of the PDACs (54.8%; 51 of 93) showed negative DKK3 staining in the epithelium, 30.0% (27 of 93) had a weak signal, and only 16.1% (15 of 93) displayed a moderate to intense DKK3 expression, irrespective of the tumor grade (Figure 4A,B; Figure S4C, Supporting Information).