DKK3 was identified as a key regulator of multiorgan regeneration, specifically in the recovery from acute pancreatitis.[12] To investigate the role of DKK3 during pancreatic tumorigenesis, we crossed a ubiquitous Dkk3 knockout allele (D) into LSL‐KrasG12D/+ (K); Ptf1aCre/+ (C) mice (KC), to generate homozygous DDKC and heterozygous DKC mouse models (Figure1A). Here, CALCA is linked to acute pancreatitis.