At first glance, our evidence for an early tumor‐suppressive role of DKK3 seems at odds with prior work in a floxed KPC model, where Dkk3 deletion reduced invasiveness and prolonged survival.[19] That rapid, Trp53‐deficient setting likely obscured early, context‐dependent DKK3 functions. The gene discussed is DKK3; the disease is neoplasm.