PARP1 and obesity due to melanocortin 4 receptor deficiency: Consistently, PARP1 activation has been shown to counteract obesity‐induced adipocyte senescence through SREBP1c–PARP1 signaling axis.[66] Moreover, PARP1 is highly expressed in several long‐lived species, such as the naked mole‐rat, where it contributes to efficient DNA repair and genomic maintenance, thereby promoting longevity.[67] Elevated PARP1 activity has also been observed in the cells of human centenarians, suggesting a possible role in lifespan extension.[68, 69] However, other studies suggested a context‐dependent detrimental effect of PARP1 overactivation.