KRAS and cancer: When considering individual cancer types (and limiting to genes with pathogenic somatic variants seen in more than one CFTR PV carrier with that cancer type), the following genes more frequently had pathogenic somatic variants in CFTR PV carriers than in the corresponding cancer types in the COSMIC database: KIT in GI tract (identified in 66.7% of CFTR PV carriers with GI cancers; Sidak p = 0.0007); and KRAS in esophageal (40.0%; Sidak p = 0.0023).