Intriguingly, compared to other host receptors of SARS-CoV-2, such as ACE2, ASGR1, KREMEN1, and TMEM106B exhibits broader and higher expression levels in both cell lines and tissues (Figure S7b and c), implying that TMEM106B may facilitate the infection of ACE2-negative cells in diverse tissues. This evidence concerns the gene ACE2 and infection.