For example, early dysregulation of the gene coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) can be seen in HD mice, human HD neurons (Liu et al., 2024a) and HD brain organoids (Lisowski et al., 2024; Liu et al., 2024a). The gene discussed is CHCHD2; the disease is Huntington disease.