Interestingly, we found coexpression of COL18A1 and the neural-signal-related receptor ITGA5 in normal tissues near multiple tumor boundaries, rather than in normal tissues far from the tumor, which may further validate the role of COL18A1-ITGA5 in promoting tumor cell migration and invasion in tumor-neural crosstalk (Figure S15C). This evidence concerns the gene ITGA5 and neoplasm.