Proteomic data generated from the prefrontal cortex of lithium-treated animal models revealed significant changes associated with cytoskeletal proteins including MAP2, SNAP-25, and clathrin light chain B. The downregulation of MAP2 and SNAP-25 denoted lithium's possibility in normalising aberrant synaptic vesicle cycling and cytoskeletal instability that are unique to BD pathology. Here, SNAP25 is linked to Behcet disease.