Research using the human AML cell lines HL60 and THP-1, as well as the murine AML model expressing the MLL-AF9 fusion gene, revealed that interleukin 6 (IL6) promotes chemoresistance by enhancing MFN1-mediated mitochondrial fusion and boosting OXPHOS [129]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.