OPA1 and breast carcinoma: For example, knocking out OPA1 and DNML1 sensitizes cell lines of ovarian carcinoma, melanoma, breast cancer, lung cancer, and pancreatic cancer to the second mitochondrial-derived activator of caspases (SMAC) mimetics; LCL161, BV6, and Birinipant, which block the inhibitors of apoptosis (IAP) family of proteins.