Deregulation of TGF-β1 has been proposed for multiple neurological disorders including AIDS dementia complex, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), MS, anxiety, depression, and schizophrenia (Kashima and Hata, 2018). The gene discussed is TGFB1; the disease is early-onset autosomal dominant Alzheimer disease.