In conclusion, our analysis suggests that TALDOD is a pleiotropic disorder that must be considered when exploring cases in infancy involving unexplained hepatosplenomegaly, congenital heart disease, and failure to thrive, especially in consanguineous families. While there is presently no specific treatment available, focused molecular analysis of the TALDO1 gene in amniotic fluid or chorionic villi can provide significant assistance to affected families in making informed reproductive decisions. This evidence concerns the gene TALDO1 and Failure to thrive.