EPO and anemia: Although the cause of this condition is unknown, there are several common factors: neonatal presentation with Coombs-negative jaundice and anemia, diagnosis made exclusively by the presence of more than 5% pyknocytes on peripheral blood smear, and positive results from treatments such as phototherapy, erythrocyte transfusion, and recombinant human erythropoietin, leading to complete remission with no residual effects [5].