After six months of insulin pump therapy, significant improvements (p<0.05) were observed in hemoglobin A1C (HbA1c) or glucose management indicator (GMI) levels, Percentage of time spent in target blood glucose range (TIR) per day, Percentage of time below target glucose range (TBR) per day, percentage of time very low below target glucose range per day, Frequency of hypoglycemia per week, diabetic ketoacidosis (DKA) admissions, and meal time flexibility. The gene discussed is INS; the disease is diabetic ketoacidosis.