One theory that has been brought forward proposing the anti‐inflammatory effects of GLP‐1RAs to be a potential improvement of the dysfunctional intestinal barrier associated with the metabolic syndrome via GLP‐1R‐mediated effects on gut microbiota composition, mucosal healing, motility, and local inflammation.20, 52, 53, 54, 55. The gene discussed is GLP1R; the disease is metabolic syndrome.