Annotation of SNPs within the high‐impact PRSs Pt_inter and Pt_TCA_cycle (an innovation in itself for prioritizing variants) pinpointed lead SNPs: rs714948 (PVR, effect on PVR expression known [61]), rs57537848 (NECTIN2), rs6859 (NECTIN2, previously linked to cognitive decline trajectories [77]), and rs620807 (BLOC1S3, a significant hit in prior tissue‐specific analyses [78]), with NECTIN2 levels associated with AD risk [79]. This evidence concerns the gene NECTIN2 and Mental deterioration.