The RNA‐seq analysis of AD mouse brain tissue validated the differential expression of multiple genes from our ceRNA network (ABCG2, B4GALT1, CDKN1A, CLOCK, FGF7, GJA1, KLF6, RBL2, XRCC6), miRNA targets (CDKN1A, CFL2, GJA1, HMGB2, SUZ12), and PRS‐derived genes (APOE, CBLC, ZNF112), confirming the pathogenic relevance of our multi‐omics findings. The gene discussed is HMGB2; the disease is Alzheimer disease.