INPP5D and Alzheimer disease: While their individual roles in T‐cell function/neuroinflammation (hsa‐miR‐155 [61]), mitochondrial biogenesis (TFAM targeting by hsa‐miR‐155 [62]; INPP5D association [63]), Aβ reduction/cognitive function (hsa‐miR‐124‐3p via synaptic mitochondria [64, 65]), and memory/glucose metabolism (hsa‐miR‐181a‐5p via mitochondrial ETC [66, 67]) are recognized, our innovation is the comprehensive identification of these miRNAs through MCC scoring within our AD‐specific ceRNA network and, critically, proposing a unifying mitochondrial‐centered perspective for their diverse actions in AD pathogenesis.