The RNA‐seq analysis of AD mouse brain tissue validated the differential expression of multiple genes from our ceRNA network (ABCG2, B4GALT1, CDKN1A, CLOCK, FGF7, GJA1, KLF6, RBL2, XRCC6), miRNA targets (CDKN1A, CFL2, GJA1, HMGB2, SUZ12), and PRS‐derived genes (APOE, CBLC, ZNF112), confirming the pathogenic relevance of our multi‐omics findings. Here, APOE is linked to Alzheimer disease.