The overlap of seven genes (APOE, CDKN1A, CLOCK, COL5A2, HMGB2, RBL2, XRCC6) between chronic neurodegenerative conditions and acute oxidative stress demonstrates the conserved transcriptional response patterns and validates their relevance to oxidative stress‐related pathways in AD pathogenesis. The gene discussed is HMGB2; the disease is Alzheimer disease.