INS and type 2 diabetes mellitus: A small study revealed higher plasma Aβ42 levels in insulin users [355], although it has also been reported that insulin use reduces the odds of pathological CSF Aβ42 levels in T2D patients after adjusting for educational level and cardiovascular comorbidities, and higher insulin doses also reduce the odds of t-tau/Aβ42 alterations, while detected effects seem to be dependent on metabolic control [318].