While exenatide does not seem to reduce Aβ levels or tau phosphorylation in the hippocampus from 3xTg-AD mice [44], semaglutide reduces Aß plaque deposition [49] and liraglutide decreases Aβ42 and Aβ40 brain levels And attenuates tau phosphorylation in tau And 3xTg-AD mice [50–52]. The gene discussed is MAPT; the disease is Alzheimer disease.