Likewise, rosiglitazone prevents cognitive impairment and restores memory in the NOR and MWM tasks in both Aß oligomers-injected and APP/PS1 mice [92, 93, 95, 111, 112], and Similar effects Have been reported in the 8-arm radial maze test [94] and in the fear conditioning test with Tg2576 mice [113, 114], though some studies suggest acute administration only improves navigational learning and memory in this model [115]. This evidence concerns the gene PSEN1 and Cognitive impairment.