The α-glucosidase inhibitor acarbose increases AKT phosphorylation specifically in female 3xTg-AD mice fed high-fat/high-sugar diet, indicating increased mTOR activity, and it shows sex-specific effects on autophagy: it decreases p62 levels in Male 3xTg-AD mice, suggesting enhanced autophagic flux, whereas elevates beclin-1 levels in females, suggesting autophagic initiation [288]. This evidence concerns the gene MTOR and Alzheimer disease.