SMAD3 and cancer: This is visualized left to each heatmap and included known tumor suppressors (e.g. bendamustine: ACSM3, CCNG1, SMAD3; cladribine: CELF2, MSRA, PPP3CC; fludarabine: CEP164, GNG7, PDLIM2), known cancer drivers (e.g. bendamustine: EIF3M, MYB, RPL27A; cladribine: SPOCK2, RNF13, PCM1; fludarabine: ALDOC, CD9, SMC4), or genes known that they can have both of these roles (e.g. bendamustine: CEACAM1, PTPN12; cladribine: DLEU1, GLI1, CCAR2; fludarabine: DLL1, GALNT6, MATK).