Many of these overlapping genes are known to play important roles in cancer and some of them were already reported in relation to leukemia (Supplementary Fig. S14, leukemia-associated genes: SP140 for bendamustine; SAMHD1, CCAR2, PCM1, PP1R14B, SP140, PDLIM2 for cladribine; RUNX2, COIL, SP140, PDLIM2 for fludarabine). This evidence concerns the gene RUNX2 and leukemia.