This included for example for bendamustine EIF3M involved in cell proliferation, cell cycle progression and cell death  [52], SMAD3 involved in epithelial-to-mesenchymal transition, tumor suppressor and metastasis formation  [53], and UBXN1 influencing EGFR signaling  [54] (Fig. 4). The gene discussed is UBXN1; the disease is neoplasm.