MTOR and hypophosphatemia: Other drugs known to cause hypophosphatemia include mTOR inhibitors [35], aluminum-based antacids (if taken in large quantities over a longer period of time, as they bind to phosphate in the gastrointestinal tract) [62], tyrosine kinase inhibitors (particularly imatinib) [63, 64] and vascular endothelial growth factor inhibitors [65].