Stanganelli and team conducted an interesting study that did not focus on the global methylation pattern but aimed to investigate the promoter methylation of various suppressor genes, such as p16INK4A, p15 INK4B, ARF, p27KIP1, TP73, RASSF1A, and SOCS-1, in patients with MGUS and MM. This evidence concerns the gene RASSF1 and Miyoshi myopathy.