SUV-based PPP criteria were most predictive of PSA-PFS in combined ADT + radiotherapy.<h4>Conclusion</h4>In BCR PCa, RECIP 1.0 best predicts OS, PPP criteria better predict PSA progression, and PROMISE nomograms provide a single-timepoint approach to OS risk stratification.<h4>Trial registration number</h4>ACTRN ACTRN12615000608561. The gene discussed is KLK3; the disease is posterior cortical atrophy.