A strongly decreased protein by C3-LHF1 was CMTM4 (Fig. 7D, depicted in blue), an essential part of the IL17 receptor responsible for limiting tissue damage in autoimmune diseases (Mezzadra et al, 2017; Knizkova et al, 2022), suggesting that the response is more fine-tuned than just detrimental. The gene discussed is CMTM4; the disease is autoimmune disease.