Under normal physiological conditions, isovaleryl-CoA is oxidized by isovaleryl-CoA dehydrogenase (IVD) to 3-methylcrotonyl-CoA, entering β-oxidation and ketogenesis to yield acetyl-CoA, thereby fueling energy production and biosynthetic processes that sustain tumor growth (Dimou et al, 2022). Here, IVD is linked to neoplasm.