Over the last decades, the KMT2A recombinome has been unraveled and currently exhibits 107 direct KMT2A fusions (KMT2A::X), 16 out-of-frame fusions to partner genes, and 16 reciprocal KMT2A fusions (X::KMT2A), all associated with the development of acute leukemia in patients [8]. Here, KMT2A is linked to acute leukemia.