LSC genes such as FAM30A, NYNRIN, ARHGAP22, CPXM1, SOCS2 or CDK6 regained function and were highly expressed within the CD19+ population on day 70, whereas the majority of LSC genes was downregulated in the CD19- population on day 70 (see Fig. 7C) These transcription data demonstrate that leukemia stem cell like genes are not only present within the first 7 to 14 days of culture. The gene discussed is SOCS2; the disease is leukemia.