Furthermore, there were positive correlations between lung viral load and VAT viral load, and between lung inflammation and antiviral response, and VAT levels of Mx1, Cd4, and Cd8. In stark contrast, aged mice exhibited numerous positive correlations between lung pathology markers (epithelial lesions and emphysema), lung inflammation, and lung antiviral response with WAT features, predominantly in VAT. Here, CD4 is linked to pulmonary emphysema.