WARS1 and neoplasm: In this work, we integrate peripheral blood mononuclear cell (PBMC) transcriptomes, tissue datasets, immunohistochemistry, and large-scale databases (TCGA) to assess WARS1 expression and its associations with mutational landscape, including tumor mutational burden (TMB), microsatellite instability (MSI), and copy number variation (CNV), as well as signaling pathways and immune–stromal interactions.