GCK and type 2 diabetes mellitus: Also, in support of perturbed coordination of stimulus-secretion coupling, we identified a de-coordinated NDCG containing regulators of glycolysis and a de-coordinated NDCG (“Glucose response”) with a high density of key regulators of beta cell function, including GCK (the rate-limiting enzyme in glucose metabolism63), suggesting perturbed glucose sensing in T2D beta cells.