For T2D risk GWAS41, we saw an enrichment in the module “Insulin Secretion” (p-adj = 4.5e-6) and remarkably, when limiting the analysis to 14 high-confidence genes (fine-mapped and missense)42, five of the 32 genes in the module still overlapped with those 14 genes (Odds ratio 129; p-adj = 6.08e-8) (Fig. S3A, B). This evidence concerns the gene INS and type 2 diabetes mellitus.