SPIRE1 and type 2 diabetes mellitus: To test the predictive power of dGCNA in identifying genes involved in T2D-related processes, we selected seven genes (TMEM176A/B (“Microfilaments”), DBI (“Proliferation”), CEBPG (“UPR”), DSTN (“Ribosome”), GABARAP (“Ribosome”), SPIRE1 (“UPR”), ATRAID (“Lysosome”)) without a well-known presence or function in human beta cells that were highly ranked in five of the NDCGs (Fig. 2C).