Furthermore, the fraction of TUNEL positive cells in the PAM treatment group was much higher than that in the PA-MCM treatment group (Fig. 6F, G), while the fraction of Ki67 positive cells was significantly lower, indicating that the presence of macrophages reduces the tumor cell death and the suppressive effect on tumor cell proliferation induced by CAP treatment in vivo (Fig. 6H, I). Here, MKI67 is linked to neoplasm.