After that, IL-10 (an effective anti-inflammatory cytokine) released by these M2 macrophages was recognized and caught by its specific receptors on the membrane of tumor cells, thereby activating the STAT1/STAT3 signaling pathway, which then alleviated the level of ER stress in tumor cells induced by CAP treatment, restored cellular homeostasis and rescued the tumor cells from multiple programmed cell death modes. Here, STAT3 is linked to neoplasm.