Mechanistically, LINC01198 directly associates with TAOK1/2 to inhibit TAOK1/2 phosphorylation and thereby elicits Hippo signaling through TAOK/LATS axis, which redistributes YAP/TAZ into nucleus and promotes the expression and secretion of IL-1β to support vemurafenib resistance in melanoma. The gene discussed is TAOK1; the disease is melanoma.