Among the nine lncRNAs with higher expression in the HExo group, lncRNA RP11-213H15.4 (Ensembl Transcript ID: ENST00000607854), also known as LUCAT1 (www.lncipedia.org), stood out due to its significant association with chemoresistance in NSCLC, colon cancer, and osteosarcoma [20, 21]. Here, LUCAT1 is linked to osteosarcoma.