In contrast, the tumor-specific cluster C3 appears less differentiated with features typical of CD56brightCD16neg NK cells (NCAM1, CD2, CD27, SELL, CD69) (Fig. 4M, N) as well as a signature of tissue residency (CD69 and ITGA1) and of TGF-β-induced genes (SMAD7, TGFB1, PMEP1, SKIL) (Fig. 4O). The gene discussed is SMAD7; the disease is neoplasm.