Interestingly, Ccl2 has previously been shown to induce Lcn2 in Snail (+) tumor cells through its autocrine actions.48 To investigate whether Lcn2 levels are regulated through a Piezo1-dependent autocrine effect of Ccl2, we first confirmed the expression of the Ccl2 receptor CCR2 in BMMSCs and found that it was significantly upregulated in KO BMMSCs (Fig. 7a). Here, LCN2 is linked to neoplasm.