PIEZO1 and neoplasm: Interestingly, Ccl2 has previously been shown to induce Lcn2 in Snail (+) tumor cells through its autocrine actions.48 To investigate whether Lcn2 levels are regulated through a Piezo1-dependent autocrine effect of Ccl2, we first confirmed the expression of the Ccl2 receptor CCR2 in BMMSCs and found that it was significantly upregulated in KO BMMSCs (Fig. 7a).