AD is a multifactorial disorder characterised by the intricate interplay of several key pathological hallmarks, including the extracellular accumulation of amyloid-beta (Aβ) plaques, the intracellular aggregation of neurofibrillary tangles composed of hyperphosphorylated tau protein, chronic neuroinflammation, progressive synaptic dysfunction, cerebrovascular alterations, protein clearance, mitochondrial function, neurochemical and receptor alterations, neurogenesis, neuroprotection, medical risk factors, and lifestyle [13,14]. Here, MAPT is linked to Alzheimer disease.