CD8A and melanoma: Bcl6fl/fl CD4-cre mice, which lack BCL6 in both CD4 and CD8 T cells, starting at the double-positive stage of T-cell development, showed inhibited growth of MC38, LLC1 (Lewis lung carcinoma), and B16F10 (melanoma) tumors compared with Bcl6fl/fl control mice (Fig S2A–G).