On day 8 post-inoculation (DPI 8) of MC38, Bcl6fl/fl Gzmb-cre mice had more tumor-infiltrating, effector IFNγ+ CD8 T cells compared with Bcl6fl/fl mice, though significantly reduced proportions of IFNγ+ CD8 T cells were observed in both groups by DPI 20 (Fig 2A). This evidence concerns the gene IFNG and neoplasm.