It has been associated with increased migraine frequency, severity, and risk of chronification.10Weight loss reduces systemic inflammation and mitigates metabolic contributors, such as insulin resistance, oxidative stress, and cerebrovascular dysregulation.27Thus, the GLP-1 RAs directly exert dual benefits: through their anti-inflammatory and neuroprotective mechanisms, and by improving metabolic variables that worsen headache burden.25 This evidence concerns the gene GCG and Insulin resistance.