INS and Hypoglycemia: These typically result from prolonged fasting, caloric restriction, dehydration, or hypoglycemia.6When this last one is the cause, the headache often arises after at least eight hours without food and is relieved by eating.6, 33Clinically, it presents as a widespread pain, mild-to-moderate and nonpulsatile, in the frontal region.23Although hypoglycemia is uncommon with GLP-1 RAs alone, the risk increases when used in combination with insulin or sulphonylureas.