PPARGC1A and essential thrombocythemia: The intricate role of genetics in the etiology of ET is underscored by the high prevalence of positive family history in patients, ranging from 20 to 90%, and the phenomenon of genetic anticipation, where tremor manifests at an earlier age in successive generations.43, 44Genome-wide association studies (GWAS) have identified several genetic variants in genes such asLINGO1,SLC1A2,STK32B,PPARGC1A, andCTNNA3linked to ET, though these findings have yet to be replicated consistently.