9 Li Li L L Karanika Karanika S S Yang Yang G G Enzalutamide-induced “BRCAness” and PARP inhibition is a synthetic lethal therapy for castration-resistant prostate cancer Enzalutamide-induced “BRCAness” and PARP inhibition is a synthetic lethal therapy for castration-resistant prostate cancer Sci Signal Sci Signal 2017 2017 10 10 eaam7479 eaam7479. The gene discussed is PARP1; the disease is Familial prostate cancer.