For example, models of selective vulnerability and connectivity can recover the brain‐wide patterns of regions becoming affected in sequence over the course of different diseases.[18] Using such models, the rates of general classes of pathological processes have been quantified,[12] and the interaction of beta‐amyloid and tau aggregation in Alzheimer's disease (AD) has been elucidated.[19]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.