RYR2 and Alzheimer disease: Food‐grade nanosilica (E 551) and dietary supplement nanosilver (Ag‐NPs), which serve as anti‐caking agents and antimicrobials, respectively, were used to investigate the common toxicity mechanisms of food‐grade nanoparticles.[16, 17] Exposure to E 171 triggered pathological and epigenetic changes in the mouse brain, and WGBS revealed the risk of AD instigated by E 171 via RyR‐Ca2+ signaling.