By measuring the serum levels of immune regulatory cytokines including IL10, IL12p70, IFN‐γ and TNF‐α, it was shown that combination of F127ZIF‐8AB680 with anti‐PD‐1 augmented the systemic production of anti‐tumor immunostimulatory cytokines (IL12p70, IFN‐γ and TNF‐α) while suppressing the immunosuppressive cytokine (IL‐10) indicating a systemic boosting of the anti‐tumor immune responses by the combinational therapy in EGFR‐mutant NSCLC in vivo (Figure S16c–f, Supporting Information). Here, TNF is linked to neoplasm.