Previous studies have demonstrated that elevated levels of adenosine in the TME suppresses the activity of immune effector cells, including T cells, DCs, NK cells and macrophages, further promoting an immunosuppressive environment.[20, 21, 22, 23] Inhibition of CD73, the primary enzyme responsible for adenosine production, could represent a promising strategy to counteract adenosine‐associated immune suppression and enhance the efficacy of ICIs in EGFR‐mutant NSCLC. Here, NT5E is linked to non-small cell lung carcinoma.