YAP1 and neoplasm: Given its critical role in regulating cell proliferation, apoptosis, senescence, and the tumor microenvironment, the Hippo pathway has garnered significant attention in recent years.[1, 52, 53, 54] Dysregulation of the Hippo pathway, particularly low expression or functional loss of its core kinases MST1/2 and LATS1/2, leads to aberrant activation of downstream effectors YAP.