TRIM25 has been reported to exert the E3 ubiquitin ligase activity depending on its RING domain.[35, 36] When we overexpressed TRIM25 in ESCC cells, hnRNPAB expression decreased with wild‐type TRIM25, but not with TRIM25 mutants lacking the RING or PS domain (Figure 4F). This evidence concerns the gene TRIM25 and esophageal squamous cell carcinoma.