In the present study, we have demonstrated that tumorigenic tRF‐22 enhances the stabilization of hnRNPAB, increases the expression and secretion of TGFβ2, and reinforces the infiltration of PMN‐MDSCs into tumors, which collectively contribute to immune suppression and ICB resistance in ESCC. Here, TGFB2 is linked to esophageal squamous cell carcinoma.