HMGCS2 and familial dilated cardiomyopathy: We found that the expression of Cyp1a1 and Hmgcs2 was significantly upregulated in the DCM samples, the expression of Hk2 was significantly downregulated in the DCM samples, Idh1, Dlst and Txnrd1 Nfe2l2 did not reach statistical significance (Fig 10, S2 File).