IDH2 and acute myeloid leukemia: The isocitrate dehydrogenase (IDH) enzyme family comprises three distinct isoforms (IDH1, IDH2, and IDH3) that serve as critical catalytic components in the TCA cycle [54].To investigate the impact of IDH mutations on cardiac remodeling, researchers generated mice bearing hematopoietic cells with an Idh2R140Q mutation [55], which mimics one of the most common IDH1/2 mutations in acute myeloid leukemia (AML) patients.