HK2 and diabetic cardiomyopathy: The expression of 7 hub genes were further verified to study the effect of cuproptosis on diabetic cardiomyopathy.The results showed 4 of them were differentially expressed(Fig 12, S3 File).They were Cyp1a1 (up),Hmgcs2 (up),IDH1 (up) and HK2 (down).The expression of Cyp1a1, Hmgcs2, IDH1 and HK2 were consistent with the predicted result.