NFKB1 and diabetes mellitus: The copper content in scalp hair and blood is significantly higher in diabetic patients compared to those without diabetes [21], copper ions lead to glutathione (GSH) depletion by covalently binding to protein sulfhydryl groups, which increases ROS generation and subsequently induces the expression of the gene Cyp1a1 through the negative regulation of the NF-κB signaling pathway [43].