CYP1A1 and familial dilated cardiomyopathy: Additionally, copper ions also induce the expression of the gene Cyp1a1 by activating the AP-1 signaling pathway [43].Overexpression of Cyp1a1 can produce excessive ROS which in turn promotes fatty acid peroxidation and inhibits the activity of mitochondrial respiratory chain, leading to myocardial injuries [40].Therefore, Cyp1a1 may influence the pathogenesis and progression of DCM through cuproptosis.