The area under curve (AUC) of Cyp1a1, Hmgcs2, Hk2, Idh1, Txnrd1, Nfe2l2 and Dlst for DCM was 0.847, 1.0, 0.918, 0.796, 0.694, 0.673,0.571 respectively in the GSE5606 dateset, with Cyp1a1, Hmgcs2, HK2 and Idh1 demonstrating good diagnostic value (Fig 11). Here, HK2 is linked to familial dilated cardiomyopathy.