MYBPC3 and hydrops fetalis: Since the lead SNP rs139616510 at the MYBPC3 locus has a low MAF (~ 0.006%) in the UKB and a relatively higher MAF (0.5%) in East Asians, we alternatively evaluated its association with echocardiographic traits in a subset of the China PEACE 5p-HF Study who went through echocardiography (N ≈ 3000).