In addition to the side effects mentioned in the instructions, adverse events such as decreased blood albumin, parathyroid hemorrhage, increased human chorionic gonadotropin, parathyroid cyst, precocious puberty, pancreatic atrophy, cardiac death, cardiac valve vegetation, foetal heart rate deceleration abnormality, mitral valve calcification or stenosis, arrhythmia and monocytopenia were also observed in a certain proportion, which warrants further attention. The gene discussed is ALB; the disease is Arrhythmia.