In case of liver inflammation related genes (IL-1β, TNF-α, IL-6, IL-18, CCL20, and NF-κB) their expression levels were significantly (P < 0.05, Fig 6) upregulated and IL-1RN was significantly (P < 0.05, Fig 6) downregulated in the liver of hyperlipidemia group. Here, IL1RN is linked to hyperlipidemia.