This could be attributed to the protective role of MSCs-Exo+EVOO against hepatic steatosis via promoting lipid oxidation related factors, PPARα, CPT-1, and ACOX, involved in fatty acid oxidation and suppressing synthesis of fatty acid via controlling PPARα, CPT-1A, SREBP-1, and FAS expression. The gene discussed is ACOX1; the disease is fatty liver disease.