Notably, TMEM220-AS1, TMEM238L, SOX6, SMAD7, TCF7L2, and PYGL were significantly downregulated in colon cancer, whereas LINC02257, PCAT1, CASC8, and POU5F1B were significantly upregulated in colon cancer. This evidence concerns the gene POU5F1B and malignant colon neoplasm.