MRC1 and neoplasm: While our findings illuminate EIF2B4’s molecular network, certain limitations warrant consideration: The resolution of immune infiltration analysis based on qPCR markers (e.g., CD68, CD8A) may be confounded by tumor purity and cellular heterogeneity, which we have now complemented with targeted flow cytometry in syngeneic tumors (CD3+CD8+ T cells, CD4+ Foxp3+ Tregs, and F4/80+ CD206+ M2 macrophages).