Following rigorous statistical controls using HEIDI-outlier testing (p < 0.05) and SMR analysis (p > 0.05), five genes maintained causal associations with AILD pathogenesis: CASZ1, AIF1, SLC16A10, EEPD1, and XRCC3 (Fig. 4F). The gene discussed is XRCC3; the disease is angioimmunoblastic T-cell lymphoma.