Due to its overexpression in various tumortypes and the preferentiallocation at the membrane site, mesothelin (MSLN) represents an attractivemolecule for targeted therapies., In addition, MSLN hasa role in cancer cell adhesion and metastasis., Arecent analysis of more than 12,000 tumors identified various cancertypes that might be particularly well suited for anti-MSLN drugs,such as ovarian carcinoma, mesothelioma, and adenocarcinomas of thepancreas, lung, stomach, esophagus, and the colorectum. Here, MSLN is linked to cancer.